Sam, a shy but creative mouse who lives in a library, decides to write and illustrate his own stories which he places on the shelves with the other library books but when children find the tales, they all want to meet the author.

Following the deaths of her husband and son, Helen Cartwright returns to her hometown in England after living abroad for sixty years. Her only wish is to die quickly and without fuss, and she retreats from the world into a life of dull routine. Then one winter night, a chance encounter with a mouse sets Helen on a surprising journey.

Mouse Mistress Hildegarde musters all her ingenuity to keep a large colony of church mice safe from the exterminator and to see that they make it through the dangerous Blessing of the Animals.

A small but effervescent overnight guest tries the patience of a curmudgeonly bear who needs absolute quiet to fall asleep.

Dr. De Soto, a mouse dentist, copes with the toothaches of various animals except those with a taste for mice, until the day a fox comes to him in great pain.

When three costumed trick-or-treaters come to Mouse's door, he crawls into one of their candy-filled bags to see what Halloween is all about.

Albert and Wanda want to invite a friend over to play on a rainy day, but they soon count fifteen mice in the walls of the People House.

Mrs. Brice has twenty-five mice and they all do everything together.

Taking a mouse to the movies can lead to letting him do other things, such as making a snowman, listening to Christmas carols, and decorating the Christmas tree.

Chester and Wilson share the same exact way of doing things, until Lilly moves into the neighborhood and shows them that new ways can be just as good.